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・ Higashi-Kawaguchi Station
・ Higashi-Kishiwada Station
・ Higashi-Kitazawa Station
・ Higashi-Kiyokawa Station
・ Higashi-Koganei Station
・ Hieu Minh Ngo
・ Hieu Minh Nguyen
・ Hieu Van Le
・ Hiew
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・ Hiezan
・ Hiezu, Tottori
・ HIF
・ HIF Akademi
・ HIF hydroxylase
HIF prolyl-hydroxylase
・ HIF prolyl-hydroxylase inhibitor
・ HIF-1 alpha IRES
・ HIF1A
・ HIF1AN
・ HIF3A
・ HIFA (disambiguation)
・ Hifajat
・ Hifana
・ Hifazat
・ Hifazat (1973 film)
・ Hifazat (1987 film)
・ Hifazat Ullah Khan
・ HIFF
・ HIFI (TV channel)


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HIF prolyl-hydroxylase : ウィキペディア英語版
HIF prolyl-hydroxylase
HIF prolyl-hydroxylase is an enzyme involved in the HIF (Hypoxia-inducible factor) signalling pathways, and is the target for a set of therapeutic drugs called HIF prolyl-hydroxylase inhibitors.
Hypoxia-inducible factor (HIF) is an evolutionarily conserved transcription factor that allows the cell to respond physiologically to low concentrations of oxygen. A class of prolyl hydroxylases which act specifically on HIF has been identified; hydroxylation of HIF allows the protein to be targeted for degradation.〔 HIF prolyl-hydroxylase has been targeted by a variety of inhibitors that aim to treat stroke, kidney disease, ischemia, anemia, and other important diseases.
==References==


抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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